Article
A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity.
Human reproduction (Oxford, England) - 1 Sept 2007
Kevenaar Marlies E, Themmen Axel P N, Rivadeneira Fernando, Uitterlinden André G, Laven Joop S E, van Schoor Natasja M, Lips Paul, Pols Huibert A P, Visser Jenny A
Abstract excerpt
BACKGROUND: Anti-Müllerian hormone (AMH) inhibits primordial follicle recruitment in the mouse ovary. We hypothesize that in women AMH signaling also regulates the usage of the primordial follicle pool and hence influences the onset of menopause. Since age at menopause has a strong genetic component, we investigated the role of AMH signaling using a candidate gene approach. METHODS: In two large population-based...
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