Allelic variation at the interleukin-1 receptor antagonist gene is associated with early postmenopausal bone loss at the spine.

doi:10.1016/s8756-3282(98)00109-4

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Article

Allelic variation at the interleukin-1 receptor antagonist gene is associated with early postmenopausal bone loss at the spine.

Bone - 1 Oct 1998

Keen R W, Woodford-Richens K L, Lanchbury J S, Spector T D

Abstract excerpt

Genetic factors play an important role in determining bone mineral density (BMD) in later life, with the genetic influence mediated through effects on both peak mass and on age- and menopause-related bone loss. At menopause there is an increase in the production and activity of various cytokines...

Topics

Absorptiometry, Photon
Alleles
Biomarkers
Bone Density
Female
Femur Neck
Genetic Heterogeneity
Humans
Interleukin 1 Receptor Antagonist Protein
Lumbar Vertebrae
Middle Aged
Osteoporosis, Postmenopausal
Polymorphism, Genetic
Receptors, Interleukin-1
Sialoglycoproteins

Source

Open in PubMed

Identifiers

PMID: 9763149
DOI: 10.1016/s8756-3282(98)00109-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9763149-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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