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Mutational analysis of the mature peptide region of inhibin genes in Indian women with ovarian failure

3 Jun 2004

Abstract excerpt

BACKGROUND: Clinically, premature ovarian failure (POF) is defined as unexplained amenorrhoea (> 6 months) with a high FSH level (> 40 IU) before the age of 40 years. POF is a heterogeneous genetic disease with unknown aetiology. Inhibin and activin regulate the FSH level by their opposing actions and thus have been considered as strong candidate genes in the aetiology of POF. METHODS: We have screened inhibin...

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PMID: 15205401
DOI: 10.1093/humrep/deh342

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