Article
Inhibin: a candidate gene for premature ovarian failure.
Human reproduction (Oxford, England) - 1 Dec 2000
Shelling A N, Burton K A, Chand A L, van Ee C C, France J T, Farquhar C M, Milsom S R, Love D R, Gersak K, Aittomäki K, Winship I M
Abstract excerpt
Premature ovarian failure (POF) occurs in 1% of all women, and in 0.1% of women under the age of 30 years. The mechanisms that give rise to POF are largely unknown. Inhibin has a role in regulating the pituitary secretion of FSH, and is therefore a potential candidate gene for ovarian failure. Using single-stranded conformation polymorphism (SSCP) and DNA sequencing, DNA samples were screened from 43 women with...
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