Controversial role of inhibin α-subunit gene in the aetiology of premature ovarian failure

Abstract excerpt

BACKGROUND: Premature ovarian failure (POF) is characterized by hypergonadotropic amenorrhoea before the age of 40. Inhibin alpha-subunit (INHalpha) gene is proposed as a candidate gene due to its role in negative feedback control of FSH. METHODS: Polymorphism -16C>T of INHalpha gene was studied in 61 POF patients and 82 controls above 40 years old (C > 40). Substitution 769G>A was studied in 59 POF patients, 76...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Growth Hormone and Insulin-like Growth Factors
• Share to Reproductive Biology and Fertility
• Share to TGF-β signaling in diseases