Article
Mutation analysis of the inhibin alpha gene in a cohort of Italian women affected by ovarian failure.
Human reproduction (Oxford, England) - 1 Jul 2002
Marozzi Anna, Porta C, Vegetti W, Crosignani P G, Tibiletti M G, Dalprà L, Ginelli E
Abstract excerpt
BACKGROUND: Premature ovarian failure (POF) is a secondary hypergonadotrophic amenorrhoea affecting 1-3% of females, whose aetiology is almost unknown. However, inhibin alpha gene (INHalpha) has recently been indicated as candidate in POF pathogenesis. METHODS: We analysed patients affected by POF (n = 157) for the missense mutation (769G-->A transition) in the exon 2 of the INHalpha gene. The same analysis was...
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