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Article

p53-dependent integration of telomere and growth factor deprivation signals

5 Mar 2007

Abstract excerpt

Ectopically expressed hTERT enables p16(INK4A)(-) human mammary epithelial cells to proliferate in the absence of growth factors, a finding that has led to the hypothesis that hTERT has growth regulatory properties independent of its role in telomere maintenance. We now show that telomerase can alter the growth properties of cells indirectly through its role in telomere maintenance, without altering growth...

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Identifiers

PMID: 17360541
DOI: 10.1073/pnas.0700260104

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