Article
The alternative lengthening of telomeres phenotype in breast carcinoma is associated with HER-2 overexpression.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2009
Subhawong Andrea Proctor, Heaphy Christopher M, Argani Pedram, Konishi Yuko, Kouprina Nina, Nassar Hind, Vang Russell, Meeker Alan K
Abstract excerpt
Approximately 10-15% of human cancers do not show evidence of telomerase activity, and a subset of these maintain telomere lengths by a recombination-based mechanism termed alternative lengthening of telomeres (ALT). The ALT phenotype, relatively common in certain sarcomas and germ cell tumors, is very rare in carcinomas. In this study we describe evidence for the ALT phenotype in molecular subclasses of breast...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.