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Article

Protein phosphatase PP1-NIPP1 activates mesenchymal genes in HeLa cells.

FEBS letters - 22 May 2015

Van Dessel Nele, Boens Shannah, Lesage Bart, Winkler Claudia, Görnemann Janina, Van Eynde Aleyde, Bollen Mathieu

Abstract excerpt

The deletion of the protein phosphatase-1 (PP1) regulator known as Nuclear Inhibitor of PP1 (NIPP1) is embryonic lethal during gastrulation, hinting at a key role of PP1-NIPP1 in lineage specification. Consistent with this notion we show here that a mild, stable overexpression of NIPP1 in HeLa cells caused a massive induction of genes of the mesenchymal lineage, in particular smooth/cardiac-muscle and matrix...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25907536
DOI: 10.1016/j.febslet.2015.04.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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