Article
Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.
Developmental cell - 1 Jun 2008
Lupu Floria, Alves Annabelle, Anderson Kathryn, Doye Valérie, Lacy Elizabeth
Abstract excerpt
Serving as the primary conduit for communication between the nucleus and the cytoplasm, nuclear pore complexes (NPCs) impact nearly every cellular process. The extent to which NPC composition varies and the functional significance of such variation in mammalian development has not been investigated. Here we report that a null allele of mouse nucleoporin Nup133, a structural subunit of the NPC, disrupts neural...
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