<i>Ov</i>‐ASP‐1, the <i>Onchocerca volvulus</i> homologue of the activation associated secreted protein family is immunostimulatory and can induce protective anti‐larval immunity

Abstract excerpt

Vaccination of mice with a recombinant protein, Ov-ASP-1, the Onchocerca volvulus homologue of the activation associated secreted gene family stimulated very high titres of both IgG1 and IgG2a without adjuvant. rOv-ASP-1 was also immuno-reactive with IgG isotypes from both O. volvulus-infected (INF) and putatively immune (PI) humans, with higher IgG4 in the former group. The protein also stimulated IFN-gamma...

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