Recombinant <i>Ov</i>-ASP-1, a Th1-Biased Protein Adjuvant Derived from the Helminth <i>Onchocerca volvulus</i>, Can Directly Bind and Activate Antigen-Presenting Cells

Abstract excerpt

We previously reported that rOv-ASP-1, a recombinant Onchocerca volvulus activation associated protein-1, was a potent adjuvant for recombinant protein or synthetic peptide-based Ags. In this study, we further evaluated the adjuvanticity of rOv-ASP-1 and explored its mechanism of action. Consistently, recombinant full-length spike protein of SARS-CoV or its receptor-binding domain in the presence of rOv-ASP-1...

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