Back to search

Article

Dendritic cell-mediated responses to secreted <i>Cryptosporidium</i> effectors are required for parasite-specific CD8 <sup>+</sup> T cell responses

2023-08-18

Abstract excerpt

Cryptosporidium causes debilitating diarrheal disease in patients with primary and acquired defects in T cell function. However, it has been a challenge to understand how this infection generates T cell responses and how they mediate parasite control. Here, Cryptosporidium was engineered to express a parasite effector protein (MEDLE-2) that contains the MHC-I restricted SIINFEKL epitope which is recognized by TCR...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f24b9cd4-635e-59b5-90fb-ddd87764ad06
DOI
10.1101/2023.08.16.553566
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Dendritic cell-mediated responses to secreted <i>Cryptosporidium</i> effectors are required for parasite-specific CD8 <sup>+</sup> T cell responsesDOI 10.1101/2023.08.16.553566
Dendritic cell-mediated responses to secreted Cryptosporidium effectors promote parasite-specific CD8+ T cell responsesSemantic proximity
Intestinal cDC1s provide IL-12 dependent and independent functions required for CD4 <sup>+</sup> T cell-mediated resistance to <i>Cryptosporidium</i>Semantic proximity
The enteric pathogen <i>Cryptosporidium parvum</i> exports proteins into the cytoplasm of the infected host cellSemantic proximity
Non-coding RNAs in epithelial immunity to<i>Cryptosporidium</i>infectionSemantic proximity
Immunity to Cryptosporidium: insights into principles of enteric responses to infectionSemantic proximity
Salmonella SPI-2 type III secretion system-dependent inhibition of antigen presentation and T cell functionSemantic proximity
Analysis of intestinal epithelial cell responses to Cryptosporidium highlights the temporal effects of IFN-γ on parasite restrictionSemantic proximity
Unveiling <i>Cryptosporidium parvum</i> Sporozoite-Derived Extracellular Vesicles: Profiling, Origin, and Protein CompositionSemantic proximity
LncRNA Nostrill promotes interferon-γ-stimulated gene transcription and facilitates intestinal epithelial cell-intrinsic anti-Cryptosporidium defenseSemantic proximity
Recombinant <i>Ov</i>-ASP-1, a Th1-Biased Protein Adjuvant Derived from the Helminth <i>Onchocerca volvulus</i>, Can Directly Bind and Activate Antigen-Presenting CellsSemantic proximity
Intracellular <i>Salmonella</i> Inhibit Antigen Presentation by Dendritic CellsSemantic proximity
Skin resident memory cells generated by the <i>L. major</i> centrin gene deleted parasites mediate protective immune response analogous to leishmanizationSemantic proximity
Select a neighboring publication to make it the new centre.