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Identification of Potential Vaccine and Drug Target Candidates by Expressed Sequence Tag Analysis and Immunoscreening of<i>Onchocerca volvulus</i>Larval cDNA Libraries

1 Jun 2000

Abstract excerpt

The search for appropriate vaccine candidates and drug targets against onchocerciasis has so far been confronted with several limitations due to the unavailability of biological material, appropriate molecular resources, and knowledge of the parasite biology. To identify targets for vaccine or chemotherapy development we have undertaken two approaches. First, cDNA expression libraries were constructed from life...

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PMID: 10816503
DOI: 10.1128/iai.68.6.3491-3501.2000

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