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Vaccination against the digestive enzyme Cathepsin B using a YS1646 <i>Salmonella enterica</i> Typhimurium vector provides almost complete protection against <i>Schistosoma mansoni</i> challenge in a mouse model

2019-05-29

Abstract excerpt

Schistosoma mansoni threatens hundreds of millions of people in >50 countries. Schistosomulae migrate through the lung and adult worms reside adjacent to the intestinal mucosa. None of the candidate vaccines in current development is designed to elicit a mucosal response. We have repurposed an attenuated Salmonella enterica Typhimurium strain (YS1646) to produce such a vaccine targeting Cathepsin B (CatB), a dige...

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Literature Corpus work
c137f6a3-1f4a-52cc-8720-ab38a03539d7
DOI
10.1101/652644
Open publication

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Vaccination against the digestive enzyme Cathepsin B using a YS1646 <i>Salmonella enterica</i> Typhimurium vector provides almost complete protection against <i>Schistosoma mansoni</i> challenge in a mouse modelDOI 10.1101/652644
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