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Article

Evaluation of the Lys198Asn and -134delA genetic polymorphisms of the endothelin-1 gene.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 May 2004

Tanaka Chihiro, Kamide Kei, Takiuchi Shin, Kawano Yuhei, Miyata Toshiyuki

Abstract excerpt

Endothelin-1 (ET-1) is a potent vasoconstrictor and shows various pharmacological responses. Two single nucleotide polymorphisms in the ET-1 gene (EDN1) have been reported to be associated with blood pressure (BP). One is the Lys198Asn polymorphism, which showed a positive association with BP in overweight people. Another is the 3A/4A polymorphism (-134delA) located in the 5'-untranslated region. In this study,...

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Identifiers

PMID: 15198485
DOI: 10.1291/hypres.27.367

Genes

EDN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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