Article
Driver mutations in melanoma: lessons learned from bench-to-bedside studies.
Current oncology reports - 1 Oct 2012
Mehnert Janice M, Kluger Harriet M
Abstract excerpt
The identification of somatic driver mutations in human samples has allowed for the development of a molecular classification for melanoma. Recent breakthroughs in the treatment of metastatic melanoma have arisen as a result of these significant new insights into the molecular biology of the disease, particularly the development of inhibitors of activating BRAF(V600E) mutations. In this article the roles of...
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