Article
Genotype and phenotype of glutathione-S-transferase in patients with head and neck carcinoma.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Jun 2004
Konig-Greger Diemut, Riechelmann Herbert, Wittich Uta, Gronau Silke
Abstract excerpt
OBJECTIVE: Association of glutathione-S-transferase M1 (GSTM1) polymorphisms and cancer has been demonstrated. Possible underlying mechanisms and genotype-phenotype correlations are not adequately investigated. The aim of this study was to investigate the influence of the GSTM1-null-genotype on the level of GSTM enzyme concentration and on the enzyme activity of GST in patients with head and neck cancer (HNC)....
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