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Article

Glutathione-associated enzymes in head and neck squamous cell carcinoma and response to cisplatin-based neoadjuvant chemotherapy.

International journal of cancer - 1 Sept 2001

Cabelguenne A, Loriot M A, Stucker I, Blons H, Koum-Besson E, Brasnu D, Beaune P, Laccourreye O, Laurent-Puig P, De Waziers I

Abstract excerpt

Glutathione S-transferases (GSTs) are metabolic phase II enzymes that promote reactive metabolite elimination by conjugating them to glutathione (GSH). Because of their important role in xenobiotic metabolism and detoxification, they have been implicated in carcinogenesis processes, especially epithelium transformation. Moreover, their influence on response to chemotherapy in cancer patients has been...

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Source

Identifiers

PMID: 11477586
DOI: 10.1002/ijc.1392

Genes

GSTP1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glutathione-associated enzymes in head and neck squamous cell carcinoma and response to cisplatin-based neoadjuvant chemotherapy.PMID 11477586Read ↗

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GSTM1, GSTT1, and the risk of squamous cell carcinoma of the head and neck: a mini-HuGE review.Semantic proximity Read ↗

Clinical Management of Head and Neck Cancer Cases: Role of Pharmacogenetics of CYP2 and GSTs.Semantic proximity Read ↗

CYP1A2*1C, CYP2E1*5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients.Semantic proximity Read ↗

Polymorphisms of GSTT1 and related genes in head and neck cancer risk.Semantic proximity Read ↗

Glutathione S-transferase polymorphisms and survival from head and neck cancer.Semantic proximity Read ↗

Genetic deletions of GSTM1 and GSTT1 in head and neck cancer: review of the literature from 2000 to 2012.Semantic proximity Read ↗

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