Article
Evolution of the human immunodeficiency virus type 1 long terminal repeat promoter by conversion of an NF-kappaB enhancer element into a GABP binding site.
Journal of virology - 1 Feb 1999
Verhoef K, Sanders R W, Fontaine V, Kitajima S, Berkhout B
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) transcription is regulated by the viral Tat protein and cellular factors, of which the concentration and activity may depend on the cell type. Viral long terminal repeat (LTR) promoter sequences are therefore optimized to suit the specific nuclear envir...
Topics
- Binding Sites
- Chromosome Mapping
- DNA-Binding Proteins
- Evolution, Molecular
- GA-Binding Protein Transcription Factor
- Genetic Variation
- HIV Enhancer
- HIV-1
- HeLa Cells
- Humans
- Jurkat Cells
- Mutation
- NF-kappa B
- Promoter Regions, Genetic
- Transcription Factors
- Tumor Cells, Cultured
- Virus Replication