Article
Impact of donor and recipient cytokine genotypes on renal allograft outcome.
Transplantation proceedings - 1 May 2004
Ligeiro D, Sancho M R, Papoila A, Barradinhas A M, Almeida A, Calão S, Machado D, Nolasco F, Guerra J, Sampaio M J, Trindade H
Abstract excerpt
Allelic differences in gene promoter or codifying regions have been described to affect regulation of gene expression, consequently increasing or decreasing cytokine production and signal transduction responses to a given stimulus. This observation has been reported for interleukin (IL)-10 (-1082 A/G; -819/-592 CT/CA), transforming growth factor (TGF)-beta (codon 10 C/T, codon 25 G/C), tumor necrosis factor...
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