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Article

Cytokine gene polymorphisms predict acute graft rejection following renal transplantation.

Kidney international - 1 Jul 1999

Sankaran D, Asderakis A, Ashraf S, Roberts I S, Short C D, Dyer P A, Sinnott P J, Hutchinson I V

Abstract excerpt

BACKGROUND: The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of acute rejection, while animal models suggest a role for interleukin-10 (IL-10) in promoting graft survival. It has also been shown that polymorphisms in the TNFA gene promoter (position -308) and in the IL-10 gene promoter (position -1082) correlate with differential production of these...

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Source

Identifiers

PMID: 10411704
DOI: 10.1046/j.1523-1755.1999.00536.x

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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