Article
Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice.
The Journal of biological chemistry - 19 Apr 2002
Molotkov Andrei, Deltour Louise, Foglio Mario H, Cuenca Arnold E, Duester Gregg
Abstract excerpt
The ability of class I alcohol dehydrogenase (ADH1) and class IV alcohol dehydrogenase (ADH4) to metabolize retinol to retinoic acid is supported by genetic studies in mice carrying Adh1 or Adh4 gene disruptions. To differentiate the physiological roles of ADH1 and ADH4 in retinoid metabolism we report here the generation of an Adh1/4 double null mutant mouse and its comparison to single null mutants. We...
Topics
- Alcohol Dehydrogenase
- Animals
- Chromatography, High Pressure Liquid
- Female
- Genetic Vectors
- Genotype
- Heterozygote
- Male
- Mice
- Mice, Transgenic
- Models, Genetic