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Article

Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3.

Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002

Molotkov Andrei, Fan Xiaohong, Deltour Louise, Foglio Mario H, Martras Silvia, Farrés Jaume, Parés Xavier, Duester Gregg

Abstract excerpt

Influence of vitamin A (retinol) on growth depends on its sequential oxidation to retinal and then to retinoic acid (RA), producing a ligand for RA receptors essential in development of specific tissues. Genetic studies have revealed that aldehyde dehydrogenases function as tissue-specific catalysts for oxidation of retinal to RA. However, enzymes catalyzing the first step of RA synthesis, oxidation of retinol to...

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Identifiers

PMID: 11959987
DOI: 10.1073/pnas.082093299
PMCID: PMC122770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3.PMID 11959987Read ↗

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