The cytotoxin of Actinobacillus pleuropneumoniae (pleurotoxin) is distinct from the haemolysin and is associated with a 120 kDa polypeptide.

doi:10.1099/00221287-137-3-561

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Article

The cytotoxin of Actinobacillus pleuropneumoniae (pleurotoxin) is distinct from the haemolysin and is associated with a 120 kDa polypeptide.

Journal of general microbiology - 1 Mar 1991

Rycroft A N, Williams D, Cullen J M, Macdonald J

Abstract excerpt

Mutants of Actinobacillus pleuropneumoniae strain HK 361 (serotype 2) were isolated which were deficient in type II (Ca2(+)-dependent) haemolysin activity (Hly-). Some of the Hly- mutants secreted a potent, heat-labile extracellular cytotoxic activity against porcine alveolar macrophages. Compari...

Topics

Actinobacillus
Animals
Bacterial Toxins
Cells, Cultured
Electrophoresis, Polyacrylamide Gel
Hemolysin Proteins
Immunoblotting
Macrophages
Molecular Weight
Mutation
Swine

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