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Article

Plasticity of the ecdysone receptor DNA binding domain.

Molecular endocrinology (Baltimore, Md.) - 1 Sept 2004

Orlowski Marek, Szyszka Monika, Kowalska Agnieszka, Grad Iwona, Zoglowek Anna, Rymarczyk Grzegorz, Dobryszycki Piotr, Krowarsch Daniel, Rastinejad Fraydoon, Kochman Marian, Ozyhar Andrzej

Abstract excerpt

Ecdysteroids coordinate molting and metamorphosis in insects via a heterodimer of two nuclear receptors, the ecdysone receptor (EcR) and the ultraspiracle (Usp) protein. Here we show how the DNA-recognition alpha-helix and the T box region of the EcR DNA-binding domain (EcRDBD) contribute to the specific interaction with the natural response element and to the stabilization of the EcRDBD molecule. The data...

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Identifiers

PMID: 15192079
DOI: 10.1210/me.2004-0154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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