Article
Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis.
The Journal of investigative dermatology - 1 Jul 2004
Vasilopoulos Y, Cork M J, Murphy R, Williams H C, Robinson D A, Duff G W, Ward S J, Tazi-Ahnini R
Abstract excerpt
Atopic dermatitis is a disease with an impaired skin barrier that affects 15%-20% of children. In the normal epidermis, the stratum corneum chymotryptic enzyme (SCCE) thought to play a central role in desquamation by cleaving proteins of the stratum corneum (e.g., corneodesmosin and plakoglobin). Genetic variations within the SCCE gene could be associated with dysregulation of SCCE activity leading to an abnormal...
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