Article
Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis.
The Journal of investigative dermatology - 1 Mar 2002
Hansson Lennart, Bäckman Assar, Ny Annelii, Edlund Michael, Ekholm Elisabeth, Ekstrand Hammarström Barbro, Törnell Jan, Wallbrandt Pia, Wennbo Håkan, Egelrud Torbjörn
Abstract excerpt
Identification of tissue-specific mechanisms involved in the pathophysiology of inflammatory skin diseases could offer new possibilities to develop effective therapies with fewer systemic effects. The serine protease stratum corneum chymotryptic enzyme is preferentially expressed in cornifying epithelia. We have previously reported on increased expression of the stratum corneum chymotryptic enzyme in psoriasis....
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