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Epidermal Hyperproliferation and Decreased Skin Barrier Function in Mice Overexpressing Stratum Corneum Chymotryptic Enzyme

1 Dec 2003

Abstract excerpt

Stratum corneum chymotryptic enzyme (SCCE; also known as kallikrein 7) is a serine protease that may have an important role in the skin desquamation process. We have recently described transgenic mice overexpressing human SCCE in suprabasal epidermal keratinocytes, leading to increased epidermal thickness, hyperkeratosis, dermal inflammation and signs of severe pruritus in older animals. In order to further...

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PMID: 15040472
DOI: 10.1080/00015550310005924

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