Article
The first knockout mouse model of retinoblastoma.
Cell cycle (Georgetown, Tex.) - 1 Jul 2004
Zhang Jiakun, Schweers Brett, Dyer Michael A
Abstract excerpt
The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene identified in humans (Friend, et al., 1986) and the first tumor suppressor gene knocked out by targeted deletion in mice (Jacks, et al., Clarke, et al., Lee, et al., 1992). Children with a germline mutation in one of their RB1 alleles are likely to experience bilateral multifocal retinoblastoma; however, mice with a similar...
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