Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The RB1 Story: Characterization and Cloning of the First Tumor Suppressor Gene

1 Nov 2019

Abstract excerpt

The RB1 gene is the first described human tumor suppressor gene and plays an integral role in the development of retinoblastoma, a pediatric malignancy of the eye. Since its discovery, the stepwise characterization and cloning of RB1 have laid the foundation for numerous advances in the understanding of tumor suppressor genes, retinoblastoma tumorigenesis, and inheritance. Knowledge of RB1 led to a paradigm shift...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Ocular Oncology and Treatments
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31683923
DOI: 10.3390/genes10110879

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RB1 Story: Characterization and Cloning of the First Tumor Suppressor GenePMID 31683923Read ↗

RB1: a prototype tumor suppressor and an enigma.Semantic proximity Read ↗

The Biology of Retinoblastoma.Semantic proximity Read ↗

Recent progress in retinoblastoma: Pathogenesis, presentation, diagnosis and managementSemantic proximity Read ↗

Retinoblastoma: from discovery to clinical managementSemantic proximity Read ↗

Molecular Biological Research on the Pathogenic Mechanism of RetinoblastomaSemantic proximity Read ↗

Retinoblastoma: from disease to discovery.Semantic proximity Read ↗

Novel insights into RB1 mutation.Semantic proximity Read ↗

Clinical characteristics and germline mutation spectrum of RB1 in Chinese patients with retinoblastoma: A dual-center study of 145 patients.Semantic proximity Read ↗

Genetics in ophthalmology: molecular blueprints of retinoblastomaSemantic proximity Read ↗

Etiology including epigenetic defects of retinoblastoma.Semantic proximity Read ↗

Molecular biology of the human retinoblastoma gene.Semantic proximity Read ↗

The retinoblastoma gene: a prototypic and multifunctional tumor suppressor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.