Article
Calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein RC3.
The European journal of neuroscience - 1 Jul 2003
van Dalen Jacqueline J W, Gerendasy Dan D, de Graan Pierre N E, Schrama Loes H, Gruol Donna L
Abstract excerpt
RC3 is a neuronal calmodulin-binding protein and protein kinase C substrate that is thought to play an important regulatory role in synaptic transmission and neuronal plasticity. Two molecules known to regulate synaptic transmission and neuronal plasticity are Ca(2+) and calmodulin, and proposed mechanisms of RC3 action involve both molecules. However, physiological evidence for a role of RC3 in neuronal Ca(2+)...
Topics
- Animals
- Calcium
- Calcium Signaling
- Calmodulin-Binding Proteins
- Cells, Cultured
- Cerebral Cortex
- Fluorescent Dyes
- Fura-2
- Immunohistochemistry
- Magnesium
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Nerve Tissue Proteins