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Article

Alpha-1-antitrypsin is produced by human neutrophil granulocytes and their precursors and liberated during granule exocytosis.

European journal of haematology - 1 Jun 2011

Clemmensen Stine N, Jacobsen Lars C, Rørvig Sara, Askaa Bjarke, Christenson Karin, Iversen Martin, Jørgensen Marianne H, Larsen Maria T, van Deurs Bo, Ostergaard Ole, Heegaard Niels H, Cowland Jack B, Borregaard Niels

Abstract excerpt

Alpha-1-antitrypsin (A1AT) is an important inhibitor of neutrophil proteases including elastase, cathepsin G, and proteinase 3. Transcription profiling data suggest that A1AT is expressed by human neutrophil granulocytes during all developmental stages. A1AT has hitherto only been found associated with azurophile granules in neutrophils indicative of A1AT expression being restricted to the promyelocyte stage. We...

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PMID: 21477074
DOI: 10.1111/j.1600-0609.2011.01601.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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