Modification of substrate-binding site of glutamyl endopeptidase from Bacillus intermedius.

doi:10.1093/protein/gzh050

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Article

Modification of substrate-binding site of glutamyl endopeptidase from Bacillus intermedius.

Protein engineering, design & selection : PEDS - 1 May 2004

Demidyuk I V, Romanova D V, Nosovskaya E A, Chestukhina G G, Kuranova I P, Kostrov S V

Abstract excerpt

Glutamyl endopeptidases (GEPs) are serine proteases belonging to the chymotrypsin structural family. Although the family as a whole has been described in detail, the molecular mechanism underlying strict substrate specificity of GEPs remains unclear. The most popular hypothesis attributes the key role in recognition of the charged substrates by GEPs to the conserved amino acid His213 (chymotrypsin numbering...

Topics

Bacillus
Binding Sites
Histidine
Insulin
Mutation
Serine Endopeptidases
Substrate Specificity

Source

Open in PubMed

Identifiers

PMID: 15187226
DOI: 10.1093/protein/gzh050

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