Article
Quiescent phenotype of tumor-specific CD8+ T cells following immunization.
Blood - 1 Oct 2004
Monsurrò Vladia, Wang Ena, Yamano Yoshisha, Migueles Stephen A, Panelli Monica C, Smith Kina, Nagorsen Dirk, Connors Mark, Jacobson Steven, Marincola Francesco M
Abstract excerpt
In a human melanoma model of tumor antigen (TA)-based immunization, we tested the functional status of TA-specific CD8+ cytotoxic T lymphocytes. A "quiescent" phenotype lacking direct ex vivo cytotoxic and proliferative potential was identified that was further characterized by comparing its transcriptional profile to that of TA-specific T cells sensitized in vitro by exposure to the same TA and the T-cell growth...
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