Article
Phenotype and functional characterization of long-term gp100-specific memory CD8+ T cells in disease-free melanoma patients before and after boosting immunization.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2008
Walker Edwin B, Haley Daniel, Petrausch Ulf, Floyd Kevin, Miller William, Sanjuan Nelson, Alvord Greg, Fox Bernard A, Urba Walter J
Abstract excerpt
PURPOSE: Effective cancer vaccines must both drive a strong CTL response and sustain long-term memory T cells capable of rapid recall responses to tumor antigens. We sought to characterize the phenotype and function of gp100 peptide-specific memory CD8+ T cells in melanoma patients after primary gp100(209-2M) immunization and assess the anamnestic response to boosting immunization. EXPERIMENTAL DESIGN:...
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