Article
Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa.
Blood - 15 Sept 2004
MacKenzie Farrell, Duriez Patrick, Larrivée Bruno, Chang Linda, Pollet Ingrid, Wong Fred, Yip Calvin, Karsan Aly
Abstract excerpt
Notch proteins comprise a family of transmembrane receptors. Ligand activation of Notch releases the intracellular domain of the receptor that translocates to the nucleus and regulates transcription through the DNA-binding protein RBP-Jkappa. Previously, it has been shown that the Notch4 intracellular region (N4IC) can inhibit endothelial sprouting and angiogenesis. Here, N4IC deletion mutants were assessed for...
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