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Article

BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium.

Blood - 3 Nov 2011

Helbing Thomas, Rothweiler René, Ketterer Elena, Goetz Lena, Heinke Jennifer, Grundmann Sebastian, Duerschmied Daniel, Patterson Cam, Bode Christoph, Moser Martin

Abstract excerpt

The endothelium plays a pivotal role in vascular inflammation. Here we study bone morphogenetic protein (BMP) signaling in endothelial inflammation and in particular the role of BMPER, an extracellular BMP modulator that is important in vascular development and angiogenesis. Using the BMP antagonist dorsomorphin or BMP2 as an agonist we show that BMP signaling is essential for the inflammatory response of...

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Topics

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Share to Bone Morphogenetic Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemotaxis, Leukocyte

Share to Endothelium, Vascular

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Share to Inflammation Mediators

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Source

Identifiers

PMID: 21900199
DOI: 10.1182/blood-2011-03-339762

Genes

BMPER
KLF2
BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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