Article
Murine hepatocyte cell lines promote expansion and differentiation of NK cells from stem cell precursors.
Hepatology (Baltimore, Md.) - 1 Jun 2004
Bordoni Veronica, Alonzi Tonino, Agrati Chiara, Poccia Fabrizio, Borsellino Giovanna, Mancino Giorgio, Fimia Gian Maria, Piacentini Mauro, Fantoni Antonio, Tripodi Marco
Abstract excerpt
While fetal liver is a major hematopoietic organ, normal adult liver provides a suitable microenvironment for a variety of immune cells and, in several pathological conditions, may become a site of extramedullary hematopoiesis. The direct influence of hepatocytes on hematopoietic cell differentiation is poorly understood. We have previously reported that the Met murine hepatocyte (MMH) untransformed hepatocytic...
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