Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium.

doi:10.1083/jcb.132.6.1133

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Article

Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium.

The Journal of cell biology - 1 Mar 1996

Block G D, Locker J, Bowen W C, Petersen B E, Katyal S, Strom S C, Riley T, Howard T A, Michalopoulos G K

Abstract excerpt

Mature adult parenchymal hepatocytes, typically of restricted capacity to proliferate in culture, can now enter into clonal growth under the influence of hepatocyte growth factor (scatter factor) (HGF/SF), epidermal growth factor (EGF), and transforming growth factor alpha (TGFalpha) in the prese...

Topics

Adult
Base Sequence
Biomarkers
Cell Differentiation
Cell Division
Cell Lineage
Cells, Cultured
Collagen
Culture Media, Serum-Free
Drug Combinations
Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation

Hepatocyte Growth Factor

Humans

Keratins

Laminin

Liver

Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 8601590
DOI: 10.1083/jcb.132.6.1133
PMCID: PMC2120765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8601590-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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