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Article

Differentiation of liver epithelial (stem-like) cells into hepatocytes induced by coculture with hepatic stellate cells.

Biochemical and biophysical research communications - 24 May 2002

Nagai Hirokazu, Terada Kunihiko, Watanabe Go, Ueno Yasuharu, Aiba Namiko, Shibuya Tomomi, Kawagoe Masami, Kameda Takashi, Sato Mitsuru, Senoo Haruki, Sugiyama Toshihiro

Abstract excerpt

The liver is believed to contain stem cells that can differentiate into either hepatocytes or biliary epithelial cells. In the present study, we established a nonhepatocytic epithelial cell line from the normal livers of adult rats. The established cells, designated HSL cells, were immunoreactive against alpha-fetoprotein, but neither albumin nor cytokeratin 19. To demonstrate the differentiation potential of HSL...

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Identifiers

PMID: 12054673
DOI: 10.1016/S0006-291X(02)00406-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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