Article
Fetal liver-derived mesenchymal stromal cells augment engraftment of transplanted hepatocytes.
Cytotherapy - 1 Jul 2012
Joshi Meghnad, B Patil Pradeep, He Zhong, Holgersson Jan, Olausson Michael, Sumitran-Holgersson Suchitra
Abstract excerpt
BACKGROUND AIMS: One important problem commonly encountered after hepatocyte transplantation is the low numbers of transplanted cells found in the graft. If hepatocyte transplantation is to be a viable therapeutic approach, significant liver parenchyma repopulation is required. Mesenchymal stromal cells (MSC) produce high levels of various growth factors, cytokines and metalloproteinases, and have...
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