Article
DNA Sequence analysis of the PorB protein of nonserotypeable serogroup C ET-15 meningococci suggests a potential mutational hot spot on their serotype antigens.
Journal of clinical microbiology - 1 Jun 2004
Law Dennis K S, Henderson Averil M, Tsang Raymond S W
Abstract excerpt
The nucleotide sequences of the PorB proteins from 28 nonserotypeable serogroup C ET-15 meningococci recovered from invasive meningococcal disease cases were determined. PCR amplification of the porB genes responsible for encoding the serotype antigen was used for DNA sequence determination and identification of the nature of the serotype antigen. DNA sequencing revealed that three strains were of serotype 2a,...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Bacterial
- Immunohistochemistry
- Meningococcal Vaccines
- Molecular Sequence Data
- Mutation
- Neisseria meningitidis, Serogroup C
- Porins
- Rabbits
- Sequence Analysis, DNA
- Serotyping