Article
Allelic diversity of the two transferrin binding protein B gene isotypes among a collection of Neisseria meningitidis strains representative of serogroup B disease: implication for the composition of a recombinant TbpB-based vaccine.
Infection and immunity - 1 Sept 2000
Rokbi B, Renauld-Mongenie G, Mignon M, Danve B, Poncet D, Chabanel C, Caugant D A, Quentin-Millet M J
Abstract excerpt
The distribution of the two isotypes of tbpB in a collection of 108 serogroup B meningococcal strains belonging to the four major clonal groups associated with epidemic and hyperendemic disease (the ET-37 complex, the ET-5 complex, lineage III, and cluster A4) was determined. Isotype I strains (with a 1.8-kb tbpB gene) was less represented than isotype II strains (19.4 versus 80.6%). Isotype I was restricted to...
Topics
- Alleles
- Animals
- Antibodies, Bacterial
- Bacterial Vaccines
- Base Sequence
- Blood Bactericidal Activity
- Carrier Proteins
- Genetic Variation
- Immune Sera
- Iron-Binding Proteins