Class 1 outer membrane protein of Neisseria meningitidis: epitope analysis of the antigenic diversity between strains, implications for subtype definition and molecular epidemiology.

Abstract excerpt

The VR1 and VR2 regions of the class 1 protein have been sequenced from a number of meningococcal strains, including non-subtypable strains and strains of apparently identical subtype. The amino acid sequences have been used to construct synthetic peptides for mapping subtype-specific epitopes. The majority of epitopes was found to be located in VR2 at the apex of a predicted surface-exposed loop. A single amino...

Topics

• Amino Acid Sequence
• Antibodies, Monoclonal
• Antibody Specificity
• Bacterial Outer Membrane Proteins
• Base Sequence
• Epitopes
• Genetic Variation
• Molecular Sequence Data
• Neisseria meningitidis
• Peptide Fragments