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Article

Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies.

PLoS medicine - 1 Apr 2006

Ye Zheng, Song Honglin, Higgins Julian P T, Pharoah Paul, Danesh John

Abstract excerpt

BACKGROUND: Glutathione S-transferases (GSTs) are known to abolish or reduce the activities of intracellular enzymes that help detoxify environmental carcinogens, such as those found in tobacco smoke. It has been suggested that polymorphisms in the GST genes are risk factors for lung cancer, but a large number of studies have reported apparently conflicting results. METHODS AND FINDINGS: Literature-based...

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Source

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Identifiers

PMID: 16509765
DOI: 10.1371/journal.pmed.0030091
PMCID: PMC1391981

Genes

GSTM1
GSTM3
GSTT1
GSTP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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