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Article

Oct4/Sox2 binding sites contribute to maintaining hypomethylation of the maternal igf2/h19 imprinting control region.

PloS one - 1 Jan 2013

Zimmerman David L, Boddy Craig S, Schoenherr Christopher S

Abstract excerpt

A central question in genomic imprinting is how parental-specific DNA methylation of imprinting control regions (ICR) is established during gametogenesis and maintained after fertilization. At the imprinted Igf2/H19 locus, CTCF binding maintains the unmethylated state of the maternal ICR after the blastocyst stage. In addition, evidence from Beckwith-Wiedemann patients and cultured mouse cells suggests that two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24324735
DOI: 10.1371/journal.pone.0081962
PMCID: PMC3855764

Genes

CTCF

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Related research

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Oct4/Sox2 binding sites contribute to maintaining hypomethylation of the maternal igf2/h19 imprinting control region.PMID 24324735Read ↗

Role of CTCF binding sites in the Igf2/H19 imprinting control region.Semantic proximity Read ↗

Sox-Oct motifs contribute to maintenance of the unmethylated H19 ICR in YAC transgenic mice.Semantic proximity Read ↗

CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Identification of the sequences responsible for maternal <i>H19</i> -ICR hypermethylation with Beckwith-Wiedemann syndrome-like overgrowth in miceSemantic proximity Read ↗

CTCF maintains differential methylation at the Igf2/H19 locus.Semantic proximity Read ↗

The H19 Imprinting Control Region Mediates Preimplantation Imprinted Methylation of Nearby Sequences in Yeast Artificial Chromosome Transgenic MiceSemantic proximity Read ↗

Identification of responsible sequences which mutations cause maternal H19-ICR hypermethylation with Beckwith-Wiedemann syndrome-like overgrowth.Semantic proximity Read ↗

<i>H19</i> Imprinting Control Region Methylation Requires an Imprinted Environment Only in the Male Germ LineSemantic proximity Read ↗

IVF results in de novo DNA methylation and histone methylation at an Igf2-H19 imprinting epigenetic switchSemantic proximity Read ↗

Oct motif variants in Beckwith-Wiedemann syndrome patients disrupt maintenance of the hypomethylated state of the H19/IGF2 imprinting control region.Semantic proximity Read ↗

CTCF elements direct allele-specific undermethylation at the imprinted H19 locus.Semantic proximity Read ↗

Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic miceSemantic proximity Read ↗

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