Article
Beta-catenin gene alteration in glandular stomach adenocarcinomas in N-methyl-N-nitrosourea-treated and Helicobacter pylori-infected Mongolian gerbils.
Cancer science - 1 Jun 2004
Cao Xueyuan, Tsukamoto Tetsuya, Nozaki Koji, Mizoshita Tsutomu, Ogasawara Naotaka, Tanaka Harunari, Takenaka Yoshiharu, Kaminishi Michio, Tatematsu Masae
Abstract excerpt
The goal of this study was to elucidate whether beta-catenin gene mutations might contribute to glandular stomach carcinogenesis in Helicobacter pylori (H.pylori)-infected Mongolian gerbils. Firstly, exon 3 of gerbil beta-catenin cDNA, a mutation hot spot, was cloned and sequenced and found to have 89.3% homology with the human form and 95.5% with the rat and mouse forms. Peptide sequence in this region was shown...
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