Alpha-1 Antitrypsin Levels and Phenotypes in Patients with Asthma and COPD in Appalachian East Tennessee.

doi:10.2147/COPD.S619871

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Article

Alpha-1 Antitrypsin Levels and Phenotypes in Patients with Asthma and COPD in Appalachian East Tennessee.

International journal of chronic obstructive pulmonary disease - 1 Jan 2026

Dhand Rajiv, Wadi Ghassan, Ferris Jennifer, Onar Gulsah Sofia, Terry Paul, Heidel Robert Eric, Nemykina Yuliya

Abstract excerpt

Purpose: Alpha-1 Antitrypsin Deficiency (A1ATD) is associated with an increased risk of emphysema and chronic obstructive pulmonary disease (COPD). In view of the high prevalence of chronic respiratory diseases in East Tennessee and limited data on A1AT phenotypes in this area, we determined A1AT allele frequency among patients with COPD, asthma, or asthma-COPD overlap (ACO) in our clinic population. Patients and...

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Topics

Humans
Female
Phenotype
Tennessee
Middle Aged
Male
Retrospective Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Asthma

alpha 1-Antitrypsin Deficiency

Pulmonary Disease, Chronic Obstructive

Aged

Genetic Predisposition to Disease

alpha 1-Antitrypsin

Biomarkers

Gene Frequency

Prevalence

Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome

Lung

Source

Open in PubMed Open full text

Identifiers

PMID: 42741722
DOI: 10.2147/COPD.S619871
PMCID: PMC13573784

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