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Bioflavonoids as Poisons of Human Topoisomerase IIα and IIβ

26 Apr 2007

Abstract excerpt

Bioflavonoids are human dietary components that have been linked to the prevention of cancer in adults and the generation of specific types of leukemia in infants. While these compounds have a broad range of cellular activities, many of their genotoxic effects have been attributed to their actions as topoisomerase II poisons. However, the activities of bioflavonoids against the individual isoforms of human...

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PMID: 17458941
DOI: 10.1021/bi7000664

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